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Even though all four volunteers were young and healthy, the degree of increase (1.6~14-fold) reflected individual variability in carnitine functions in blood and tissues

Among them, 243 samples underwent RAS testing, with only 45 patients having detectable mutations and a total of 21 mutations were detected in the NS5A gene, with no clinically significant resistance observed in the NS5B gene (Table 1)

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Furthermore, although AD brain tissue frequently exhibits mitochondrial failure, new research has shown that peripheral mononuclear blood cells' mitochondrial activities have changed ( 3.2 Impaired electron transport chain function Alzheimer's disease is marked by decreased activity in several enzymatic complexes critical for ATP production, including the pyruvate dehydrogenase complex, -ketoglutarate dehydrogenase complex, complex I (NADH ubiquinone oxidoreductase), complex IV (cytochrome oxidase), and complex V (ATPase) (43, 44)