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Data availability The datasets used during the current study are available from Abbreviations COPD: Chronic obstructive pulmonary disease PCA: Principal Component Analysis CDH5: Cadherin 5 RRM1: Ribonucleotide reductase catalytic subunit M1 SUPV3L1: Suv3 like RNA helicase KRT78: Keratin 78 CRD: Chronic respiratory disease COPD-BE: COPD co-existing with bronchiectasis COPD-MD: COPD co-existing with metabolic syndrome MPV: Mean platelet volume DEPs: Differentially expressed proteins GO: Gene Ontology KEGG: Kyoto Encyclopedia of Genes and Genomes HP: Haptoglobin HBB: Hemoglobin subunit beta VCL: Vinculin HBA1: Hemoglobin subunit alpha 1 CA1/2: Carbonic anhydrase 1/2 SOD1: Superoxide dismutase 1 FGA: Fibrinogen alpha chain PRDX2: Peroxiredoxin 2 ALDOA: Aldolase, fructose-bisphosphate A TNC: Tenascin C CAT: Catalase PRM: Parallel Reaction Monitoring B4GAT1: Beta-1,4-glucuronyltransferase 1 GNPTG: N -Acetylglucosamine-1-phosphate transferase subunit gamma ADAMTSL4: ADAMTS like 4 CFP: Complement factor properdin EXTL2: Exostosin like glycosyltransferase 2 SAA1: Serum amyloid A1 CRP: C-reactive protein ORM1/2: Orosomucoid 1/2 DEMs: Differentially expressed metabolites WGCNA: Weighted gene co-expression network analysis BALF: Bronchoalveolar lavage fluid RAB26: Member RAS oncogene family SERPINA1: Serpin family A member 1 GOLD: Global Initiative for Obstructive Lung Disease PBMCs: Peripheral blood mononuclear cells References Barnes PJ

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