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In atherosclerosis, inflammation plays an important role, since oxidized lipids activate macrophages and T lymphocytes, which lead to the secretion of inflammatory cytokines (TNF-alpha, IL-1, IL-6) and the appearance of ROS

However, such signals were hardly observed in the Si group treated with MTX for 1 week and only slightly for 2 weeks (Fig

Acknowledgments The corresponding author, AS, is thankful to authors for their collaborative efforts in writing this paper

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Physical activity is strenuous, fasting is a little bit stressful, heat, cold, these things are all types of little intermittent challenges