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Humane endpoints included indicators, such as huddled posture, immobility, ruffled fur, failure to eat, hypothermia (colonic temperature of 20%, inability to stand, agonal breathing, severe muscular atrophy, severe ulceration or uncontrolled bleeding

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Graphical abstract Access this article Similar content being viewed by others Data availability The data supporting the findings of this study are available from the corresponding author upon request

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These events lead to liver damage by loss of cell membrane integrity