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Randomized controlled study is needed to confirm these initial findings

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[1] Because the cypionate ester markedly increases lipophilicity, the subcutaneous or intramuscular depot undergoes gradual enzymatic hydrolysis, releasing free estradiol that is chemically identical to endogenous estrogen and capable of binding to nuclear estrogen receptors in target tissues

The main theoretical concern is angiogenesis BPC-157 promotes new blood vessel formation, which is great for healing but theoretically undesirable if you have a condition where blood vessel growth is problematic (active cancer is the primary example)

They are not instant wrinkle fillers, but with consistent use they can be part of a routine focused on softer-looking lines and better-looking skin quality