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The permutation results suggest that the three-SNP model is the best fit for our data, though several SNPs may be good candidates for future studies

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Glutamate dehydrogenase and glutamate production The evidence that glutamate may serve as a second messenger to amplify insulin secretion comes from identifying a gain-of-function mutation in the gene encoding glutamate dehydrogenase (GDH), an enzyme that catalyses conversion of -ketoglutarate to glutamate