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10.1038/cdd.2017.149 Cell Death Differ

383,384 During extract preparation, native cellular membranes are disrupted at the lysis step and self-assemble to form vesicles 385 (e.g., cytoplasmic/periplasmic membrane vesicles in bacteria

While former studies suggested that regressive forms of onset were not common in ASD, more recent investigations indicate that the rates are quite high and may be under-reported