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Gut Permeability and Its Effect on Neuroinflammation Intestinal permeability, often referred to in the context of the permeable gut, is a significant contributor to a multitude of neuroinflammatory processes central to various neurodegenerative diseases

It is a tripeptide molecule made up of three amino acids glutamic acid, cysteine, and glycine

InterPro in 2022

Moreover, the inactivation of ubiquitination and proteasomal degradation of -catenin in the intact destruction complex have been shown to saturate the destruction complex, preventing further engagement and thereby degradation of -catenin (Li et al., 2012)

This means most of a high-dose supplement remains in the gastrointestinal tract, though the direct link to digestive symptoms is not well established