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Han J, He Y, Zhao H, Xu X

However, several reports highlight that while generally safe, these injections can sometimes cause adverse effects, most notably hypersensitivity and anaphylactic reactions

Ther Adv Hematol 29(11):2040620720955000 Sagi V, Mittal A, Tran H, Gupta K (2021) Pain in sickle cell disease: current and potential translational therapies

A randomized clinical trial on the use of selenium in patients with mild GO provided evidence for a beneficial effect

Since there are deficiency alleles with mutations outside the coding sequence and there are individuals with three mutations, it is not possible to assume that all coding region mutations are responsible for the disease