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Oxidative injury to the endothelium reduces the circulatory level of NO due to the decline in its synthesis by uncoupling eNOS via ROS-induced oxidation and depletion of BH4 [138, 139]

One particularly easy amide to break is acyl imidazole

Moreover, HK2 is closely related to the survival of patients with breast cancer and mediates the immunosuppression of breast cancer cells through the upregulation of programmed death ligand-1 (PD-L1) expression [39]

SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid protein oligomerization and memory loss in mouse model of Alzheimer disease

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