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J Recept Signal Transduct Res (2021) 41(4):35762

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Thus, experiments with ovariectomized (OVX) rats have shown a reduction in the anti-oxidant activity of superoxide dismutase (SOD) in the hippocampus, a process that contrasts with an increase in the pro-oxidant enzyme monoamine oxidase (MAO) in the same region (Huang and Zhang, 2010)

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Nevertheless, it is important to note that many studies demonstrating 3-HK cytotoxicity employ supraphysiological concentrations [157], underscoring the need to define pathologically relevant exposure levels in depression

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