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Key findings: GH response to Hexarelin decreased significantly after 16 weeks of continuous administration (Rahim et al., 2000) Desensitization is dose-dependent higher doses accelerate receptor downregulation The effect is reversible with washout periods Hexarelin shows more desensitization than GHRP-2, which in turn shows more than Ipamorelin 4.2 Prolactin Elevation Hexarelin produces the highest prolactin increase of any GHRP

Food and Drug Administration (FDA) and the European Medicines Agency (EMA) and has attracted considerable attention for drug nanoparticle development (Kumar and Kumar, 2019

Funding The work was supported by the University Natural Science Research Project of Anhui Province (YJS20210138), and Education Department Project of Zhejiang Province (Y202248486), Biodiversity Survey and Assessment Project of Ministry of Ecology and Environment in China (2019HJ2096001006)