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It was concluded that assessment of gut microbes and stool metabolites could be used for diagnosis of fibrosis in non-obese subjects with MASLD

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Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia

Indeed, preclinical models have limitations such as the difference of age, with young and health animals employed in the preclinical studies versus the majority of patients in the clinic that are aged and multi-diseased (Talbert et al., 2014