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Accumulating evidence suggests that the gut microbiota has a regulatory role in the brain behaviour

These drugs modulate opioid pathways within the CNS [243]

The neuronal circuits underlying the processing of emotional states and impacted by MDD are similarly complex and involve many structures, including the prefrontal cortex (PFC), a region heavily implicated in affective disorders and the effects of stress 9

The human GPx family contains eight isoforms, which differ significantly in tissue distribution, structural features, functional localization, and substrate selectivity, including gastrointestinal-type GPx2, which is localized in the gastrointestinal tract, plasma-type GPx3, and phospholipid peroxidation-type GPx4, etc

This suggests that different corresponding weights should be considered in NMAs to give a more realistic recommendation (48)