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Moderate chronic ingestion, eg, 4 g/day, usually leads to transient mild elevation of liver enzymes in healthy individuals 12 but can in rare cases cause acute liver failure

CYP2E1 amplifies lipid peroxidation by increasing ROS production, while its downregulation correlates with poor prognosis and tumor progression [47]

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Hirabayashi T, Yamashita M, Wada N, Takenoya F, Ikeda H, Kamei J, Ryushi T, Yamamoto N, Shioda S (2018) Analgesic effect of mineral cream containing natural spa minerals for use on the skin

Mitochondria were maloriented in two patients and degeneration of membranous organelles was seen in three cases