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Nicotine impersonates the neurotransmitter acetylcholine (ACh), and by binding to receptors ACh would usually bind to, stimulates the production of dopamine, which is involved in your bodys reward pathways

Such responses can be either in the opposite direction to the drugs effects, causing tolerance, or in the same direc- tion, mimicking drug action

The effects on the cardiovascular system can lead to an increased heart rate (10-20bpm), increased blood pressure (5-10mmHg), and reduced arterial blood flow causing dizziness and decreased endurance and stamina

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