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Well known antioxidants include vitamin C, vitamin E, and beta-carotene, but there have been approximately 4000 different flavonoids discovered thus far, which is only one type of antioxidant

Moreover, DSF appeared to induce transcriptome rewiring that minimized energy expenditures to detoxification processes and the restoration of cellular respiration

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Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size