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As oxidative stress increases, further stimulation of pro-inflammatory cytokines such as TNF- and IL-1 increases and contributes to synaptic dysfunction and neuronal degeneration (Dawi et al., 2024)

)., 302, 5646, 841, 2003, Helley MP, Pinnell J, Sportelli C, Tieu K

Resveratrol, found in red grapes and berries, has antioxidant and anti-inflammatory effects that may help mitigate cognitive decline and improve behavioral symptoms in PD (Jadidian et al

Amantadine is mainly an antiviral drug where the amantadine helps in reducing the symptoms of PD, particularly dyskinesia (involuntary movements) associated with prolonged use of levodopa

We included primary in vitro , invertebrate, and PD-specific rodent studies, epidemiologic analyses, and formulation/delivery reports relevant to oxidative stress in PD