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For example, silybins dual inhibitory effect on BRAF and SMO receptors in melanoma cells provides new targets for anti-tumor therapy ( 3 The application of silybin in neurological diseases 3.1 The impact on Alzheimers disease Research has found that silybin exerts notable anti-inflammatory and neuroprotective effects in Alzheimers disease, primarily by inhibiting the excessive activation of microglia induced by amyloid- (A)

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The study was terminated due to insufficient patient participation, inadequate Karnofsky Performance Scale (KPS) (which assesses functional impairment of patient upon illness reappearance) and the recent accessibility of FDA-approved medications, such as Avastin (bevacizumab), after the studys inception ( NCT01044966, September 2009)