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Periodontol 72 (1), 1318

6.1 Targeting the synergy between -synuclein aggregation and ferroptosis Iron overload accelerates the formation of toxic -syn oligomers, while aberrant -syn expression disrupts iron metabolism and GSH synthesis, thereby creating a vicious cycle that enhances neuronal susceptibility to ferroptosis (Chen et al., 2025)

Ferroptosis promotes an inflammatory response Ferroptosis is highly immunogenic and can induce the release of inflammatory mediators and DAMPs [63]

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Disadvantages of the model are the cost, the time involved, the need for specialized facilities, and the employment of guinea-pigs