glutathione synthesis rate-limiting step Glutathione Metabolism and Its Implications

Normally, almost all glutathione in the mitochondria is reduced glutathione, but in the presence of mitochondrial dysfunction, the proportion of oxidised glutathione increases due to the increased elimination of ROS

In autoimmune diseases such as systemic lupus erythematosus (SLE), mitochondrial damage and the release of mitochondrial DNA (mtDNA) into the cytoplasm and extracellular space have been observed [130]

In addition, IgG2-REW and IgG4-REW did not bind FcRIIIa (Fig

A comparison with the structure of glutathione reductase

References Sattler S (2017) The role of the immune system beyond the fight against infection