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The improvement in the frailty status was less compared to L-carnitine group

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Rogers AH, Garey L, Bakhshaie J, Viana AG, Ditre JW, Zvolensky MJ

Due to its polar nature, carnitine cannot diffuse freely across cell membranes and depends on specific transporters, principally OCTN2 (SLC22A5)a high-affinity (Km 46 mol/L), sodium-dependent transporter highly expressed in the brush border membrane of the renal proximal tubules [73, 74]