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the research must explicitly describe molecular mechanisms or signaling pathways and provide detailed information on curcumin formulations or delivery systems (e.g., nanoparticles, liposomes) and their effects on bioavailability or efficacy

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Platform-based approaches and in vitro models are helping predict efficacy and reduce risk, especially in hard-to-treat areas like the central nervous system (CNS)

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Ando W, Tateishi K, Hart DA et al (2007) Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells