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131 As we age, protein synthesis becomes imbalanced and is regulated by the mTOR pathway

Ongoing phase 3 trials for weight loss in non-T2D individuals are now utilizing a similar dosing protocol to that of semaglutide, starting at 0.25 mg/week with gradual titration every four weeks, up to a maximum of 2.4 mg/week [11]

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Ethics statement The trial was conducted in accordance with the Declaration of Helsinki (1996 revision) and under the principals of good clinical practice, as laid out in the International Conference on Harmonization document Good Clinical Practice Consolidated Guideline

Immunofluorescence staining was performed to assess macrophage polarization, with CD86 serving as a marker for pro-inflammatory M1 macrophages and CD206 for anti-inflammatory M2 macrophages