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Take 1 capsule twice daily with food (morning and early afternoon), or as directed by a practitioner

Curcumin showed a protective antioxidant effect against gentamycin-induced oxidative stress documented by alleviated lipid peroxides, increased levels of superoxide dismutase and glutathione, increased expression of Bcl-2, a protein protecting against oxidative stress, suppressed proapoptotic Bax, and suppressed executioner caspase in apoptosis, caspase-3

Pharmacological assessment of zebrafish-based cardiotoxicity models

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Both of these direct oxidation processes affect crucial active site cysteine residues and result in a loss of enzymatic activity (Halloran et al., 2013)