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10.1164/ajrccm.160.3.9811018 56 StockwellB

Its built from the inside out

Chem Biol Interact 1991

The SIRT1/Nrf2/GPX4 pathway was identified as a protective mechanism, with SIRT1 knockdown reversing this effect

LncRNA P53RRA can bind to Ras GTPase activating protein binding protein 1 (G3BP1) to activate the p53 pathway and retain more p53 in the nucleus, thereby exerting a pro-ferroptosis effect [170]