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Strong recommendations are typically based on high-certainty evidence (i.e., high confidence in the estimate of the effect of an intervention) and may recommend in favour of an intervention (when there is high confidence of net benefit) or against an intervention (when there is high confidence of net harm)

10.1016/j.jadohealth.2017.04.003 2

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unlike with smokers, our failure to open an era of responsibility between denial and resignation would not result only in the tragic loss of an individual life, but in a widespread disease across our entire planet.

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