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5.2 Disorders of mitochondrial long-chain fatty acid oxidation 5.2.1 Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency Clinical presentation Patients diagnosed with VLCAD deficiency (OMIM 201475) can suffer from hepatic, cardiac and muscular symptoms that can appear in infancy, but also later during adolescence or adulthood

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1), having access to food questionnaires in two independent cohorts, a Canadian prospective nutritional BIOBANK IO cohort 63 conducted in 147 patients with lung cancer eligible to receive ICI-based therapy (Supplementary Table 3a) and the French PREVALUNG cohort of patients at risk of tobacco-associated cancers 49 (Supplementary Table 1g)

Incubating human retinoic pigment epithelial cells with insulin or constitutively activating Akt kinase rapidly induces nuclear accumulation of SREBP-1a and SREBP-1c and the expression of lipogenic genes (50)