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On the other hand, systemic immune dysregulation is exemplified in systemic lupus erythematosus (SLE), where neutrophil ferroptosis synergizes with CaMKIV-CREM pathway-mediated GPX4 suppression to potentiate NETosis (Li et al., 2021)

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(6) When to pursue functional testing despite a high value Functional markers are most useful when the clinical picture argues for deficiency even though the total looks fine