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Additionally, when used in young mice, CAR-T cells were able to persist at considerable levels for up to 12 months post initial treatment and limit the onset of metabolic and physical disorders later in life

Experimental infection of cell lines has also shown that the activities of antioxidant enzymes may decrease over time 18,19 and that chemical stimulation from reactive oxygen species may even induce an upregulation of antioxidant enzymes in order to counteract oxidative stress 17

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Thus, there is a need for larger studies to fully address this issue