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PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega- O -acylceramide synthesis and skin permeability barrier

Mol Membr Biol 24:455463 McElrath MJ, Kaplan G, Nusrat A, Cohn ZA (1987) Cutaneous leishmaniasis

Bovogen Biologicals) at RT for 1 h and stained overnight with primary antibodies against -SMA (1:1,000) and collagen I (1:1,000) at 4C, followed by treatment with Alexa Fluor594-labeled secondary antibody (1:2,000

Osorio-Llanes et al., 2023)

This line of inquiry aligns with broader scientific efforts to understand how small molecules might influence the trajectory of cellular aging within an organism