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After being ingested, these phenolic compounds undergo biotransformation and are broken down in the colon by microbial enzymes yielding smaller, bioavailable molecules that can then be absorbed by the colon into the bloodstream and transported to tissues and organs (Trebatick and urakov, 2015)

These depot-specific differences stem from varied cellular composition, gene regulatory networks, and physiological functions - including distinct steroid receptor profiles, adipokine signatures, and metabolic activities (388, 389)

Sleep deprivation and oxidative stress in animal models: a systematic review

Funding Hunan Provincial Natural Science Foundation of China, 2023JJ604787, Key Research and Development Program of Hunan Province of China, 2023SK4001 Ethics declarations Competing interests The authors declare no competing interests

Adhami, M