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Gohari, G., et al

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This could have been evolutionarily important in situations of food scarcity, and explains why mammalian organisms largely rely on this pathway to sustain NAD + levels in different tissues [37,38]

[1] 1,3-BPG + ADP 3-PG + ATP The reaction has a G of 18.5 kJ/mol (4.4 kcal/mol), making it exergonic , although under cellular conditions the free energy change is +1.3 kJ/mol (+0.3 kcal/mol)