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The global period covers the procedure itself, the usual pre-procedure evaluation, and any routine same-day follow-up

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When mPTP is open, it allows the passage of solutes 1.5 kDa, which leads to mitochondrial depolarization, swelling, rupture of the outer membrane, and release of material including mtDNA and cytochrome c [36]

For healthcare professionals exploring advanced topical or systemic peptide therapies, understanding the underlying mechanisms and evidence is essential for achieving safe, predictable outcomes