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Microscopic analysis revealed a greater mononuclear count, less granulocytes, an increase in fibroblasts and superior formation of the reticulin and collagen fibres

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Next.... nature.com/articles/s4157 The evolving landscape of obesity pharmacotherapy Nature Reviews Drug Discovery, 2026 1 Obesity pharmacotherapy has moved from weight loss drugs to cardiometabolic disease-modifying therapy Obesity is now framed as a chronic, relapsing, neuroendocrine-metabolic disease, not simply a lifestyle failure

The manufacturer voluntarily discontinued the commercial product in 2008 for business reasons, not due to any safety concern