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J Magn Reson 155:106118 Zhang W, Li R, Shin R, Wang Y, Padmalayam I, Zhai L, Krishna NR (2013) Identification of the binding site of an allosteric ligand using STD-NMR, docking, and CORCEMA-ST calculations

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Abbreviations GSH: Glutathione Gpx4: Glutathione peroxidase 4 ROS: Reactive oxygen species AR: Androgen receptor BTB: Blood-testis barrier T: Testosterone H&E: Hematoxylin and eosin MDA: Malondialdehyde DEGs: Differentially expressed genes TUNEL: Terminal dUTP Nick End Labeling Cys: Cystine GSR: GSH reductase References Dardente H, Lomet D, Robert V, Decourt C, Beltramo M, Pellicer-Rubio MT

APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

C9SN modifies the immunosuppressive tumor microenvironment (ITM) by impeding glutamine metabolism on one hand, polarizing M2-TAMs to M1-TAMs, which in turn recruits and activates CTLs, while on the other hand, C968 in the nanoaugmentation amplifies the intracellular oxidative stress by inhibiting glutamine metabolism-mediated GSH deprivation, which results in severe cell death, and also enhances the immunogenic cell death (ICD) effect [122]