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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

Brian Lee, an associate professor of clinical medicine at the University of Southern California, who serves on the committee, argued as much yesterday

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Example 4: Physicochemical characterization of the pre-fusion stabilized hMPV F antigen constructs [0374] To further characterize the purity, size, and thermal stability of the protein produced from the A2-D185P and A2-T160F_N46V constructs - HP-SEC, SEC-HPLC, SEC-MALS, and nanoDSF analysis was performed