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Lastly, when comparing children with stage 3 konzo with their unaffected siblings, we found that in addition to GPx3, Zinc-alpha-2-glycoprotein (AZGP1) and Carboxypeptidase B2 (CPB2) were major contributors to group segregation, with CP protein also being identified as being a potential contributor (Fig

Leite JS, Raizel R, Hypolito TM, Rosa TD, Cruzat VF, Tirapegui J

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However, in the microcirculation, where RBCs are in close proximity to the vasculature and Hb becomes partially oxygenated, ROS released from neutrophils, macrophages, and endothelial cells can be taken up by RBCs