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Chemical Irritants: Skincare products or cosmetics containing harsh chemicals can cause inflammation and exacerbate pigmentation issues

doi: 10.1016/j.molmet.2019.06.026 47

and Moskovits, M

Unexpectedly, unmodified SOD was equally effective at catalyzing nitration as the inactivated SOD, suggesting that nitration was enhanced by metal-dependent catalysis (copper) at the active site of the enzyme