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In fact, MS was one of the first CNS diseases where gut bacteria were shown to have a causal influence in animal models: in 2011, it was demonstrated that segmented filamentous bacteria in the gut could trigger CNS-autoreactive Th17 cells and provoke an MS-like disease in mice [181]

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Investigations During an attack the blood film may show irregularly contracted cells, bite cells (indented membrane), blister cells (cells in which haemoglobin appears detached from the cell membrane), Heinz bodies and increased reticulocytes

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