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This metabolic shift enables GBM cells to maintain ATP production, generate biosynthetic intermediates, and manage redox balance even in oxygen-poor environments

Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct

The inactivation of GPX4 can be achieved through both indirect approaches, including GSH depletion, as well as direct methods involving pharmacological or genetic interventions