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Lyophilized semaglutide remains stable at -20C (-4F) for extended periods, while reconstituted solutions must be refrigerated and used within 28 days

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In addition, the negative NMO and MOG antibody tests effectively rule out neuromyelitis optica and MOG-associated disorders as alternative causes, leaving the possibility of clinically isolated syndrome (CIS) or an early demyelinating condition, such as multiple sclerosis (MS), as more probable explanations

Each of these options has its own mechanism, evidence base, and risk profile