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Knockdown of Notch3 can increase the ROS level in lung cancer cells, reduce the expression levels of GPX4 and peroxiredoxin 6 (PRDX6), and then induce lipid peroxidation to trigger cell ferroptosis [178]

2.10.1 Limitation of in-vitro model Despite their value in mechanistic research, in vitro models present several critical limitations that constrain their translational applicability (Slanzi et al., 2020)

doi: 10.1016/J.REDOX.2025.103686 373 DidierAJStieneJFangLWatkinsDDworkinLDCreedenJF

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Current clinical overview of cutaneous melanoma