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Future studies should incorporate mechanism-relevant biological markers, including serum BDNF to index neurotrophic signaling, inflammatory markers such as CRP and IL-6, measures of HPA-axis activity such as the cortisol awakening response, and neuroimaging markers (e.g., fMRI-based assessments of hippocampal connectivity), to more precisely characterize treatment response and patient stratification

It is important to note that most current insights into autophagy are based on the detection of autophagy-related factors, and accurately quantifying autophagic flux remains a significant challenge

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Characterization of symptoms and symptom clusters for type 2 diabetes using a large Nationwide Electronic Health Record Database