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as levels normalise, improved daytime energy may temporarily affect sleep-wake cycles Individual sensitivity : A small subset of people may be more sensitive to changes in B vitamin levels Formulation factors : Some B12 supplements contain additional ingredients that could affect sleepalways check product labels for stimulants like caffeine For the vast majority of people, vitamin B12 supplementation does not cause sleep disturbances when taken as directed

Patients often describe a cumulative effect each week feels slightly better than the last

Cannarella R, La Vignera S, Condorelli RA, Mongioi LM, Calogero AE

Some have plausible mechanisms and early evidence