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Choi S, Lovinger DM (1997)

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Moreover, inhibition of GS activity in TAMs induces the polarization of M2-type TAMs toward the M1 type, accompanied by a decrease in glutamine levels and increase of succinic acid and accumulation of HIF-1

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It can be seen It is evident that the Hippo pathway mainly regulates ferroptosis through the involvement of SKP2 and NOX4, providing new insights for the treatment of ccRCC