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doi: 10.3389/fphar.2023.1137783 282 DenkDPetrocelliVConcheCDrachslerMZieglerPKBraunAet al

Patients taking insulin or sulfonylureas alongside semaglutide face increased hypoglycemia risk

Mitochondria are affected by this process with loss of membrane potential and swelling followed by rupture of the outer mitochondrial membrane (OMM) and subsequent release of its contents including cytochrome c and other apoptotic mediators as well as mtDNA

Binding to intrinsic factor (IF) : Parietal cells in the stomach lining secrete intrinsic factor, a glycoprotein that binds B12 in the small intestine

Die Pathogenese beruht auf der erhhten Sekretion von Interferon alpha durch plasmazytoide dendritische Zellen, auf der Immunmodulation durch Interferon alpha und auf der erhhten Expression von IL-23 und IL-22