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Collectively, these findings broaden the implication of biomaterial-based tolerance strategies by confirming that nanoparticles can effectively deliver diverse CNS autoantigens, including PLP, MBP, and AQP4, to re-establish antigen-specific immune regulation across multiple mechanistically distinct autoimmune diseases

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Collectively, these findings indicate that lipid metabolism functions as both a pivotal pathogenic mediator and a promising therapeutic target in ALS