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We used metformin treatment to induce aging-like metabolic stress in human primary fibroblasts 14 , and combined metformin exposure with Pol I inhibition by the compounds BMH-21 and CX-5461 32,33 , with direct ATP repletion serving as a positive control

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Oxidative stress releases pro-inflammatory molecules that interact with ROS to produce inflammation, performing major role in early onset of aging and metabolic diseases [7]

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The high-carbohydrate meal reduced blood alcohol levels at peak and again two hours after drinking, while the high-protein meal by itself had no significant effect on BAC (Finnigan et al., Alcohol and Alcoholism, 1998)