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Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)

Because they produce so much energy, they also produce a lot of free radicals as a byproduct

ES Materials Manufacturing 28, 1522

Novo Nordisk knows this the higher-dose 2.4/7.2 mg trial planned for H2 2026 is designed to close that gap

The formation of aggregates can be checked by utilizing oppositely charged biopolymers such as carbohydrates and proteins as protectants to improve mechanical stability and kinetics